fulltext.study @t Gmail

Photo- and thermo-responsive assembly of liposomal membranes triggered by a gemini peptide lipid as a molecular switch

Paper ID Volume ID Publish Year Pages File Format Full-Text
28329 44070 2006 6 PDF Available
Title
Photo- and thermo-responsive assembly of liposomal membranes triggered by a gemini peptide lipid as a molecular switch
Abstract

A gemini peptide lipid composed of l-histidyl residues, hydrophobic double-chain segments, and an azobenzene spacer unit was synthesized as a photoresponsive molecular switch for assembly of liposomal membranes. Photoisomerization of the azobenzene moiety between the trans-form and the corresponding cis-form reversibly proceeded in the liquid crystalline state of the liposome formed with phospholipids, but not in the gel state below the phase transition temperature. The gemini peptide lipid with the cis-azobenzene spacer recognized Cu2+ ions to induce vesicular assembly in the liquid crystalline state of the liposomal membrane. On the other hand, the corresponding trans-form, which exhibited little affinity toward Cu2+ ions, did not act as a molecular switch for vesicular assembly. Furthermore, photo-switching behavior performed by the gemini peptide lipid was tuned using the thermotropic phase transition of the matrix membrane.

Keywords
Gemini lipid; Molecular switch; Liposome; Photoresponsive; Thermoresponsive
First Page Preview
Photo- and thermo-responsive assembly of liposomal membranes triggered by a gemini peptide lipid as a molecular switch
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us
Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology A: Chemistry - Volume 183, Issue 3, 25 October 2006, Pages 309–314
Authors
, , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us