fulltext.study @t Gmail

Light-induced toxic effects of tamoxifen: A chemotherapeutic and chemopreventive agent ☆

Paper ID Volume ID Publish Year Pages File Format Full-Text
28383 44072 2009 7 PDF Available
Title
Light-induced toxic effects of tamoxifen: A chemotherapeutic and chemopreventive agent ☆
Abstract

Tamoxifen is a powerful drug used to treat breast cancer patients, and more than 500,000 women in the U.S. are being treated with this drug. In our study, tamoxifen is found to be photomutagenic in Salmonella typhimurium TA102 at concentrations as low as 0.08 μM and reaches maximum photomutagenicity at 0.4 μM under a light dose equivalent to 20 min sunlight. These concentrations are comparable to the plasma tamoxifen concentration of 0.4–3 μM for patients undergoing tamoxifen therapy. The toxicity seems to be the result of DNA damage and/or lipid peroxidation caused by light irradiation of tamoxifen. The DNA damage caused by irradiation of ФX174 DNA in the presence of tamoxifen appears to be formation of DNA–tamoxifen covalent adducts, not single strand/double strand cleavages, and there is no oxygen involvement. This is confirmed by EPR experiments that carbon-centerd radicals are formed by light irradiation of tamoxifen and there is no singlet oxygen formation. Although superoxide radical is formed, it is not involved in DNA damage.

Keywords
Tamoxifen; Phototoxicity; HaCaT keratinocytes; Salmonella TA102; DNA damage; Lipid peroxidation
First Page Preview
Light-induced toxic effects of tamoxifen: A chemotherapeutic and chemopreventive agent ☆
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us
Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology A: Chemistry - Volume 201, Issue 1, 1 January 2009, Pages 50–56
Authors
, , , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us