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Cleavage-induced fluorescence change via hydrophilicity control: A new strategy for biological application

Paper ID Volume ID Publish Year Pages File Format Full-Text
28390 44074 2007 6 PDF Available
Title
Cleavage-induced fluorescence change via hydrophilicity control: A new strategy for biological application
Abstract

In this work, we report a novel stimuli-sensitive probe working on the principle of the cleavage-induced fluorescent change via hydrophilicity control. In our Si–Py–Ac–PEG probe, cleavage of hydrophilic PEG moiety in acidic environment induces hydrophobic interaction of pyrenes to increase their excimer emission. Our fluorescent probe (Si–Py–Ac–PEG) was successfully applied to the spotting microarray and nanoparticle suspension to demonstrate the potential of biological applications, i.e. protein chip and bioimaging.

Keywords
Hydrophilicity control; Excimer emission; Cleavage; Microarray; Biomedical imaging
First Page Preview
Cleavage-induced fluorescence change via hydrophilicity control: A new strategy for biological application
Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology A: Chemistry - Volume 188, Issues 2–3, 20 May 2007, Pages 149–154
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering