fulltext.study @t Gmail

Synthesis of N-alkyl derivatives and photochemistry of nitro (E)-3-azachalcones with theoretical calculations and biological activities

Paper ID Volume ID Publish Year Pages File Format Full-Text
28392 44074 2007 8 PDF Available
Title
Synthesis of N-alkyl derivatives and photochemistry of nitro (E)-3-azachalcones with theoretical calculations and biological activities
Abstract

Three new N-alkyl substituted nitro (E)-3-azachalconium bromides (4–6) and two new stereoselective dimerization products (7 and 8) of o-, m-, and p-nitro substituted (E)-3-azachalcones were synthesized and tested for antimicrobial and antioxidant activities. Compounds 4–6 showed very good antimicrobial activities against Escherichia coli, Pseudomonas aeruginosa, Enterococcus faecalis, Staphylococcus aureus, Bacillus cereus, and Candida tropicalis and no activity against Klebsiella pneumoniae and Yersinia pseudotuberculosis. The monomers of o-, m-, and p-nitro substituted (E)-3-azachalcones (1–3) and their N-alkyl derivatives (4–6) showed good DPPH radical scavenging activity with IC50 values in the range of 0.25–0.90 mg/mL. The dimerization product 8 showed the highest activity among the eight compounds synthesized, while compound 7 was inactive in DPPH test. Compounds 4 and 8 showed similar antioxidant activity as the standard antioxidants Trolox® and Vitamin C.The possible photochemical dimerization products of compounds 1–3 were calculated theoretically based on transition state structures. The experimentally obtained β-truxinic type dimers were also the expected products from transition state energy calculations.

Keywords
Nitro-(E)-3-azachalcones; Nitro-(E)-N-decyl-3-azachalconium bromide; Photodimerization; Antimicrobial and antioxidant activities
First Page Preview
Synthesis of N-alkyl derivatives and photochemistry of nitro (E)-3-azachalcones with theoretical calculations and biological activities
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us
Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology A: Chemistry - Volume 188, Issues 2–3, 20 May 2007, Pages 161–168
Authors
, , , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us