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Mathematical modeling to validate on-line CO2 measurements as a metric for cellulolytic biofilm activity in continuous-flow bioreactors

Paper ID Volume ID Publish Year Pages File Format Full-Text
2841 137 2015 13 PDF Available
Title
Mathematical modeling to validate on-line CO2 measurements as a metric for cellulolytic biofilm activity in continuous-flow bioreactors
Abstract

•A mathematical model for Clostridium thermocellum biofilms on cellulose sheets is formulated.•The biofilm growth model accounts for CO2 production, as measurement for microbial activity.•Excellent quantitative agreement between online CO2 measurement data and model is found.•The utility of CO2 online measurements to assess microbial growth activity is demonstrated.

A mathematical model for the growth of thin Clostridium thermocellum biofilms on cellulose sheets with penetration from the surface into the interior fiber matrix is formulated, and used to assess the potential of CO2 on-line measurements for activity of cellulolytic biofilms. The biofilm growth model is linked to a product formation model. It includes the processes of carbon substrate consumption, biofilm growth, biofilm upkeep, and carbon dioxide production. The mathematical description leads to a system of ordinary differential equations that is simple enough to lend itself to qualitative analysis, yet complex enough to capture the essential features of the system. Numerical fitting of the model against experimental data showed excellent quantitative agreement. The model substantiates the utility of on-line CO2 measurements as indicator of cellulose substrate colonization and consumption, which may be useful for reporting bioreactor performance.

Keywords
Biofilm; Cellulose; Clostridium thermocellum; CO2 on-line measurement; Dynamic modeling; Growth kinetics
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Mathematical modeling to validate on-line CO2 measurements as a metric for cellulolytic biofilm activity in continuous-flow bioreactors
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biochemical Engineering Journal - Volume 101, 15 September 2015, Pages 55–67
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
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Full-text PDF Download
Online Support
Any Questions? feel free to contact us