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Synthesis, characterization, and DNA-binding properties of the cobalt(II) and nickel(II) complexes with salicylaldehyde 2-phenylquinoline-4-carboylhydrazone

Paper ID Volume ID Publish Year Pages File Format Full-Text
28718 44087 2008 7 PDF Available
Title
Synthesis, characterization, and DNA-binding properties of the cobalt(II) and nickel(II) complexes with salicylaldehyde 2-phenylquinoline-4-carboylhydrazone
Abstract

Salicylaldehyde 2-phenylquinoline-4-carboylhydrazone (H2L), and its novel cobalt(II), nickel(II) complexes (M·HL·3H2O)·NO3 (MCo (1), MNi (2)), have been synthesized and characterized by elemental analysis, molar conductivity, mass spectra and IR spectra. The interaction of these complexes with calf-thymus DNA was investigated by UV absorption spectroscopy, fluorescence spectroscopy, circular dichroism (CD) spectroscopy, cyclic voltammetry, and viscosity measurements. The two complexes showed absorption hyperchromism in the range of 190–280 nm. The binding constant have been determined using absorption measurement and found to be 0.89 × 105 M−1 and 2.2 × 105 M−1, respectively. Results suggest that the two complexes bind to DNA via a groove binding mode.

Graphical abstractIn this paper, two novel cobalt(II), nickel(II) complexes of salicylaldehyde 2-phenylquinoline-4-carboylhydrazone (H2L) have been synthesized and characterized. The interaction of these complexes with calf-thymus DNA was investigated by UV absorption spectroscopy, fluorescence spectroscopy, circular dichroism (CD) spectroscopy, cyclic voltammetry, and viscosity measurements. Results suggest that the two complexes can bind to DNA well via a groove binding mode and the binding affinity take the order of 1 > 2.Figure optionsDownload full-size imageDownload as PowerPoint slide

Keywords
DNA; Salicylaldehyde 2-Phenylquinoline-4-carboylhydrazone; Complex; Groove binding
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Synthesis, characterization, and DNA-binding properties of the cobalt(II) and nickel(II) complexes with salicylaldehyde 2-phenylquinoline-4-carboylhydrazone
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology A: Chemistry - Volume 196, Issue 1, 30 April 2008, Pages 77–83
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
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Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
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Full-text PDF Download
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