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Beneficial effects of photo-inactive titanium dioxide specimens on plasmid DNA, human cells and yeast cells exposed to UVA/UVB simulated sunlight ☆

Paper ID Volume ID Publish Year Pages File Format Full-Text
28752 44089 2006 13 PDF Available
Title
Beneficial effects of photo-inactive titanium dioxide specimens on plasmid DNA, human cells and yeast cells exposed to UVA/UVB simulated sunlight ☆
Abstract

Photoactive TiO2 specimens extracted from commercial sunscreen lotions had been shown earlier [R. Dunford, A. Salinaro, L. Cai, N. Serpone, S. Horikoshi, H. Hidaka, J. Knowland, FEBS Lett. 418 (1997) 87] to cause damage to both DNA plasmids in vitro and to whole human skin cells in cultures by photoproduced OH radicals. This article reports on the effects of TiO2 specimens, whose particle surface was modified by a thermally assisted procedure to produce TiO2 specimens of considerably reduced photo-activity. Deactivation of the photocatalytic activity of TiO2 impacts on the kinetics of photooxidation of phenol and has a significant effect in diminishing, if not suppressing completely, damage caused to DNA plasmids, to human cells, and to yeast cells compared to non-modified specimens exposed to UVB/UVA simulated solar radiation. Photo-inactive TiO2 could be beneficial in sunscreen formulations and in polymer blends, since they also completely retain their UVB/UVA absorption/scattering (screening) characteristics. Synergistic effects of titania specimens with an organic sunscreen active agent (Padimate-O) on DNA plasmids and the survival of yeast cells in the presence of titanium dioxide, and in the presence of such UV filters as Padimate-O and Parsol 1789 (i.e., avobenzone) under UV irradiation are reported.

Keywords
Titanium dioxide; UV physical filter; Plasmid DNA; Yeast cells; Human cells; Padimate-O; Parsol 1789; Deactivation of photo-activity
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Beneficial effects of photo-inactive titanium dioxide specimens on plasmid DNA, human cells and yeast cells exposed to UVA/UVB simulated sunlight ☆
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology A: Chemistry - Volume 179, Issues 1–2, 1 April 2006, Pages 200–212
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us