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Synthesis, characterization, cytotoxic activity and DNA-binding properties of the Ln(III) complexes with ethylenediiminobi(6-hydroxychromone-3-carbaldehyde) Schiff-base

Paper ID Volume ID Publish Year Pages File Format Full-Text
28822 44094 2008 10 PDF Available
Title
Synthesis, characterization, cytotoxic activity and DNA-binding properties of the Ln(III) complexes with ethylenediiminobi(6-hydroxychromone-3-carbaldehyde) Schiff-base
Abstract

A new ligand, ethylenediiminobi(6-hydroxychromone-3-carbaldehyde) Schiff-base (L), was prepared by condensation of 6-hydroxy-3-carbaldehyde chromone (CDC) with ethylenediamine. Its three rare earth complexes have been synthesized and characterized on the basis of elemental analyses, molar conductivities, mass spectra, 1H NMR, thermogravimetry/differential thermal analysis (TG-DTA), UV–vis spectra, fluorescence spectra and IR spectra. The general formula of the complexes is [LnL·(NO3)2]·NO3 [Ln = Sm (1), Eu (2), La (3)]. Complexes 1, 2 and 3, and ligand L were subjected to biological tests in vitro using HepG2 cancer cell lines. Ligand showed significant cytotoxic activity against HepG2cancer cell lines. Spectrometric titration, ethidium bromide displacement experiments and viscosity measurements indicate that Sm(III) and Eu(III) complexes strongly bind with calf thymus DNA, presumably via an intercalation mechanism. The intrinsic binding constants of complexes 1 and 2, and ligand with DNA were 9.28 × 106, 8.40 × 106 and 4.88 × 106 M−1 through fluorescence titration data, respectively.

Keywords
CT-DNA, calf thymus DNA; L, ethylenediiminobi(6-hydroxychromone-3-carbaldehyde) Schiff-base; Tris, Tris(hydroxymethyl)-aminomethane; NMR, nuclear magnetic resonance; EB, ethidium bromide; CDC, 6-hydroxy-3-carboxaldehydes chromone; UV-vis, ultraviolet and
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Synthesis, characterization, cytotoxic activity and DNA-binding properties of the Ln(III) complexes with ethylenediiminobi(6-hydroxychromone-3-carbaldehyde) Schiff-base
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology A: Chemistry - Volume 194, Issue 1, 5 February 2008, Pages 49–58
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us