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Transient species of several fluoroquinolones and their reactions with amino acids

Paper ID Volume ID Publish Year Pages File Format Full-Text
28884 44102 2010 5 PDF Available
Title
Transient species of several fluoroquinolones and their reactions with amino acids
Abstract

The photochemistry of several fluoroquinolone antibiotics (FQs), including enoxacin (ENX), norfloxacin (NFX), and ciprofloxacin (CPX), have been investigated in neutral aqueous solution by laser flash photolysis and pulse radiolysis. Transient absorption spectra of FQs were observed and transient species were assigned. The absorption maxima (λmax) of triplet states of ENX, NFX and CPX were located at 520 nm, 620 nm and 610 nm, respectively. The radical anions of FQs were characterized by λmax = 370 nm. Reactions of the FQ triplet states with amino acids (tyrosine [TyrOH], tryptophan [TrpH], glycine [Gly] and cysteine [Cys]) were investigated in different conditions. All three FQ triplet states can oxidize TrpH and TyrOH. The FQ radical anions and oxidized radicals of TrpH (Trp) and TyrOH (TyrO) were directly observed. Under aerobic conditions, the photooxidation of TrpH and TyrOH involves both Type I and Type II mechanisms. There were no distinct quenching reactions of the FQ triplet states by Gly and Cys in N2-saturated aqueous solutions.

Keywords
Fluoroquinolone; Laser flash photolysis; Pulse radiolysis; Photochemistry; Amino acid
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Transient species of several fluoroquinolones and their reactions with amino acids
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology A: Chemistry - Volume 215, Issues 2–3, 25 September 2010, Pages 191–195
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
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Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
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