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Biocompatible protoporphyrin IX-containing nanohybrids with potential applications in photodynamic therapy

Paper ID Volume ID Publish Year Pages File Format Full-Text
28938 44107 2007 5 PDF Available
Title
Biocompatible protoporphyrin IX-containing nanohybrids with potential applications in photodynamic therapy
Abstract

Protoporphyrin IX was immobilized in the interlayer region of Mg–Al layered double hydroxides in order to produce biocompatible nanohybrids that could find applications in photodynamic therapy. Protoporphyrin IX and perfluoroheptanoic acid were also cointercalated to produce nanohybrids that combine the oxygen dissolving properties of perfluorocarbons with the photodynamic effect of the porphyrin. The various nanohybrids were characterized by using X-ray diffraction, Fourier transformed infrared spectroscopy, ultraviolet-visible spectroscopy and thermogravimetric analysis. In addition to the intercalation of protoporphyrin IX in the interlayer region of the layered double hydroxides, the X-ray diffraction pattern also showed that intercalation of perfluoroheptanoic acid resulted in the formation of a bilayer between the inorganic layers. Photooxidation experiments using substrates such as imidazole, 2,3-dimethyl-2-butene or linoleic acid, demonstrated the generation of singlet oxygen by these nanohybrids.

Keywords
Layered double hydroxide; Protoporphyrin IX; Photodynamic therapy; Perfluoroheptanoic acid
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Biocompatible protoporphyrin IX-containing nanohybrids with potential applications in photodynamic therapy
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology A: Chemistry - Volume 185, Issue 1, 1 January 2007, Pages 62–66
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us