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Production of reactive oxygen species induced by a new [60]fullerene derivative bearing a tetrazole unit and its possible biological applications

Paper ID Volume ID Publish Year Pages File Format Full-Text
28997 44112 2008 5 PDF Available
Title
Production of reactive oxygen species induced by a new [60]fullerene derivative bearing a tetrazole unit and its possible biological applications
Abstract

The wide range of physical and chemical properties of modified fullerenes has drawn increasing attention in the past few years. As part of this research, this paper describes the preparation, characterization, and photophysical properties of a new fullerene derivative chemically modified with a tetrazole. The photophysical properties were studied by EPR radical spin-trapping technique and showed that reactive oxygen species (ROS) can be produced through UVA photosensitization. EPR spin-trapping experiments with singlet oxygen (1O2) and superoxide (O2−) inhibitors (β-carotene and superoxide dismutase, respectively) revealed also that: (i) the main ROS produced is 1O2 and (ii) 1O2 is being partially dismutated to O2−. The results suggest that this derivative can be used in biological applications, as for example, in topic photodynamic therapy (PDT) as a photosensitizer.

Keywords
Fullerene C60 derivative; Electron paramagnetic resonance; Reactive oxygen species
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Production of reactive oxygen species induced by a new [60]fullerene derivative bearing a tetrazole unit and its possible biological applications
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology A: Chemistry - Volume 200, Issues 2–3, 15 December 2008, Pages 277–281
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
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