fulltext.study @t Gmail

Macroporous biphasic calcium phosphate scaffolds reinforced by poly-L-lactic acid/hydroxyapatite nanocomposite coatings for bone regeneration

Paper ID Volume ID Publish Year Pages File Format Full-Text
2903 142 2015 9 PDF Available
Title
Macroporous biphasic calcium phosphate scaffolds reinforced by poly-L-lactic acid/hydroxyapatite nanocomposite coatings for bone regeneration
Abstract

•Biomimetic scaffolds were prepared for bone regeneration.•The compressive strength of scaffold was improved by nanocomposite coating.•Such scaffolds support hBMSCs growth and proliferation.•Gradient new bone was formed after scaffold was implanted to rabbit femoral head.

Three-dimensional (3D) interconnected porous scaffolds with biomimetic hierarchical architectures and mechanical characteristics are critical for the success of bone regeneration. In this paper, biphasic calcium phosphate (BCP) scaffolds were coated with medical-grade poly-L-lactic acid/hydroxyapatite (mPLLA/HA) nanocomposites to create controlled surface roughness while remaining the interconnected porous structures. Such mPLLA/HA coatings substantially improved the compressive strength of the scaffolds to 3.17–3.95 MPa, in contrast to 0.31 MPa for the as-prepared bare porous BCP scaffolds. Moreover, these mPLLA/HA-coated porous scaffolds were demonstrated to provide excellent support to the growth and proliferation of human barrow mysenchymal stem cells (hBMSCs). The hBMSCs-seeded mPLLA/HA-coated scaffolds were implanted to large necrotic lesions in the rabbit femoral head. New bone tissues were observed after two months, followed by gradient new bone formation over months according to H&E and Masson staining analysis. These results suggest that the mPLLA/HA-coated BCP scaffolds with improved mechanical strength and osteogenesis may be applied for bone regeneration.

Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide

Keywords
BCP scaffold; Bone regeneration; Biomedical; Osteogenesis; Bone marrow mysenchymal stem cells; Viability; Biodegradation
First Page Preview
Macroporous biphasic calcium phosphate scaffolds reinforced by poly-L-lactic acid/hydroxyapatite nanocomposite coatings for bone regeneration
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us
Publisher
Database: Elsevier - ScienceDirect
Journal: Biochemical Engineering Journal - Volume 98, 15 June 2015, Pages 29–37
Authors
, , , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us