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Development of a photocurable gelatin-based gelation material for application to periodontal regeneration

Paper ID Volume ID Publish Year Pages File Format Full-Text
29087 44118 2008 6 PDF Available
Title
Development of a photocurable gelatin-based gelation material for application to periodontal regeneration
Abstract

Novel photocurable materials, comprised mixed aqueous solutions of photoreactive gelatin – gelatin partially derivatized with eosin – and polyamine, which is a polymer of N,N-dimethylaminopropylacrylamide, were designed. The materials had appropriate viscosity for shape formation at 37 °C. When photoirradiated with a clinically used visible light source, the materials were almost completely converted to hydrogels to fix their shape in the desired form within several tenths of a second. Cells that were seeded on the eosin–gelatin-coated surface showed good proliferation. Negligible cytotoxicity of eosin–gelatin was confirmed when culturing was performed in the presence of a large amount of eosin–gelatin. The developed photocurable materials could be converted to a hydrogel with desired physical property change by using a convenient curing procedure of photoirradiation at any desired time and in any shape with minimal cytotoxicity, which was appropriate for the application in periodontal tissue regeneration.

Keywords
Photocurable material; Periodontal tissue regeneration; Photoreactive gelatin; Eosin; Hydrogel
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Development of a photocurable gelatin-based gelation material for application to periodontal regeneration
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology A: Chemistry - Volume 199, Issues 2–3, 25 September 2008, Pages 255–260
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
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