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Phototransformation of the drug trazodone in aqueous solution

Paper ID Volume ID Publish Year Pages File Format Full-Text
29101 44118 2008 5 PDF Available
Title
Phototransformation of the drug trazodone in aqueous solution
Abstract

Irradiation of trazodone at 310 nm in water has been investigated. In addition to the OH-substitution in the chlorobenzene ring a peculiar dimerization of the dihydropyridine moiety leading to a cage-like product was involved in the photo-induced modification of the drug. The photoproducts, isolated by chromatographic techniques, have been identified by spectroscopic means. Further support of the structure of the cage-like product was sought by a comparison between the experimental chemical shifts and the values computed at the DFT level.

Keywords
Trazodone; Drug phototransformation; Photo-dehalogenation; Water photoaddition; Cage-like products
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Phototransformation of the drug trazodone in aqueous solution
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology A: Chemistry - Volume 199, Issues 2–3, 25 September 2008, Pages 353–357
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
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Price was $35.95
You save - $31
Price after discount Only $4.95
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