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Kinetic study of butanol production from various sugars by Clostridium acetobutylicum using a dynamic model

Paper ID Volume ID Publish Year Pages File Format Full-Text
2936 143 2015 11 PDF Available
Title
Kinetic study of butanol production from various sugars by Clostridium acetobutylicum using a dynamic model
Abstract

•A kinetic dynamic model of ABE fermentation was proposed.•Mono-, di-, hexose and pentose sugars were investigated by applying the proposed model.•Kinetic parameters were assessed by processing data from batch fermentation tests.•The kinetic model successfully simulated batch fermentation tests.

This paper presents a kinetic dynamic model of acetone–butanol–ethanol production by Clostridium acetobutylicum DSM 792 developed with the biochemical networks simulator COPASI. This model is an evolution of previous models described in the literature, updated by including various mono-, di-, hexose and pentose sugars: glucose, mannose, fructose, sucrose, lactose, xylose and arabinose. The kinetic relationships of uptake of substrate, butanol production, cell growth and cell death are also included.The batch fermentation tests were carried out at an initial sugar concentration ranging from 5 to 100 g/L. The data from the batch tests were used to assess the kinetic parameters of the model. This model gave satisfactory results for each sugar, both in terms of simulation of fermentation – the square correlation coefficient of metabolite concentrations, calculated by comparing experiments and simulations, ranged between 0.87 and 0.925 – and of comparison with the models reported in the literature.The effects of mono-, di-, hexose and pentose sugars on the growth and production of metabolites, including acids and solvents, were reviewed according to the proposed model. The low fermentation performance measured for xylose and lactose were interpreted taking into account the sugar uptake, the acid production and the hydrolysis path.

Keywords
Substrate inhibition; Product inhibition; Clostridium acetobutylicum; Dynamic modelling; Biokinetics; COPASI
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Kinetic study of butanol production from various sugars by Clostridium acetobutylicum using a dynamic model
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biochemical Engineering Journal - Volume 99, 15 July 2015, Pages 156–166
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us