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Enhanced photodynamic therapy efficacy of methylene blue-loaded calcium phosphate nanoparticles

Paper ID Volume ID Publish Year Pages File Format Full-Text
29398 44384 2015 10 PDF Available
Title
Enhanced photodynamic therapy efficacy of methylene blue-loaded calcium phosphate nanoparticles
Abstract

•CaP-MB nanoparticles were synthesized in the presence of polymer templates.•CaP protected MB from the enzymatic reduction.•CaP-MB nanoparticles exhibited enhanced PDT efficacy.•Apoptotic cell death was induced by CaP-MB nanoparticles.

Although methylene blue (MB) is the most inexpensive photosensitizer with promising applications in the photodynamic therapy (PDT) for its high quantum yield of singlet oxygen generation, the clinical use of MB has been limited by its rapid enzymatic reduction in the biological environment. To enhance PDT efficacy of MB by preventing the enzymatic reduction, we have developed a new mineralization method to produce highly biocompatible MB-loaded calcium phosphate (CaP-MB) nanoparticles in the presence of polymer templates. The resulting CaP-MB nanoparticles exhibited spherical shape with a size of under 50 nm. Fourier transform infrared (FT-IR) and zeta-potential analyses confirmed the insertion of MB into the CaP-MB nanoparticles. The encapsulation of MB in CaP nanoparticles could effectively protect MB from the enzymatic reduction. In addition, the CaP-MB nanoparticles exhibited a good biocompatibility in the dark condition and significantly enhanced PDT efficacy due to apoptotic cell death against human breast cancer cells as compared with free MB, implying that CaP-MB nanoparticle system might be potentially applicable in PDT.

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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 146, May 2015, Pages 34–43
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
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Full-text PDF Download
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