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Exposure to solar ultraviolet radiation is associated with a decreased folate status in women of childbearing age ☆

Paper ID Volume ID Publish Year Pages File Format Full-Text
29437 44397 2014 6 PDF Available
Title
Exposure to solar ultraviolet radiation is associated with a decreased folate status in women of childbearing age ☆
Abstract

•Childbearing age women were supplemented with 500 μg of folic acid for two weeks.•Following one week of measured sun exposure, serum folate degradation was assessed.•We show an association between increasing sun exposure and decreases in serum folate status.

In vitro studies indicate that folate in collected human blood is vulnerable to degradation after exposure to ultraviolet (UV) radiation. This has raised concerns about folate depletion in individuals with high sun exposure. Here, we investigate the association between personal solar UV radiation exposure and serum folate concentration, using a three-week prospective study that was undertaken in females aged 18–47 years in Brisbane, Australia (153 E, 27 S). Following two weeks of supplementation with 500 μg of folic acid daily, the change in serum folate status was assessed over a 7-day period of measured personal sun exposure. Compared to participants with personal UV exposures of <200 Joules per day, participants with personal UV exposures of 200–599 and >600 Joules per day had significantly higher depletion of serum folate (p = 0.015). Multivariable analysis revealed personal UV exposure as the strongest predictor accounting for 20% of the overall change in serum folate (Standardised B = −0.49; t = −3.75; p = <0.01). These data show that increasing solar UV radiation exposures reduces the effectiveness of folic acid supplementation. The consequences of this association may be most pronounced for vulnerable individuals, such as women who are pregnant or of childbearing age with high sun exposures.

Keywords
FFQ, food frequency questionnaire; 5-MTHF, 5-Methyltetrahydrofolate; UV, Ultraviolet; NTDs, Neural Tube Defects; ROS, Reactive Oxygen SpeciesPopulation study; Folate; Folic acid; Solar ultraviolet radiation; Photodegradation
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Exposure to solar ultraviolet radiation is associated with a decreased folate status in women of childbearing age ☆
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 131, 5 February 2014, Pages 90–95
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us