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Increase in serum 25-hydroxyvitamin-D3 in humans after sunbed exposures compared to previtamin D3 synthesis in vitro

Paper ID Volume ID Publish Year Pages File Format Full-Text
29446 44405 2013 5 PDF Available
Title
Increase in serum 25-hydroxyvitamin-D3 in humans after sunbed exposures compared to previtamin D3 synthesis in vitro
Abstract

•Sunbed exposures increase 25-hydroxyvitamin D level in humans.•Sunbed dosimetry in situ by monitoring previtamin D accumulation in vitro.•In vivo generation of 25(OH)D can be related to previtamin D synthesis in vitro.•The 25(OH)D levels linearly correlate with previtamin D concentrations in vitro.•Easy prognosis of vitamin D status after UV exposure.

Ultraviolet (UV) radiation is liable to cause skin cancer but it is the main source of vitamin D. Vitamin D photosynthesis takes place in skin at sub-erythemogenic UV doses, while larger exposures destroy vitamin D and increase DNA damage. Proper UV dosimetry is needed to obtain an optimal vitamin D status when skin cancer risk is minimal. A simple approach to such dosimetry using physically measured accumulated UV dose cannot provide a satisfactory quantification of vitamin D because of the complexity of the processes involved in vitamin D synthesis. A biological dosimeter of vitamin D synthetic UV radiation (‘D-dosimeter’) has been introduced earlier on the basis of an in vitro model of previtamin D photosynthesis. In the present study in vivo generation of 25-hydroxyvitamin D (25(OH)D) in serum of healthy volunteers exposed to UV radiation from the sunbed was accompanied by in vitro measurements of vitamin D formation using ‘D-dosimeter’. It was found that the increase in serum 25(OH)D concentration depended both on the initial 25(OH)D level and on the cumulative sunbed exposure time. The observed linear correlation between in vivo and in vitro data can be used to estimate changes in vitamin D status after UV exposure using only one pre-exposure blood sample combined with further in vitro measurements.

Keywords
UV biodosimeter; Vitamin D status; 25(OH)D level; Sunbed; UV exposure; Previtamin D photosynthesis
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Increase in serum 25-hydroxyvitamin-D3 in humans after sunbed exposures compared to previtamin D3 synthesis in vitro
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 122, 5 May 2013, Pages 32–36
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us