fulltext.study @t Gmail

Low level laser therapy accelerates bone healing in spinal cord injured rats

Paper ID Volume ID Publish Year Pages File Format Full-Text
29489 44411 2016 7 PDF Available
Title
Low level laser therapy accelerates bone healing in spinal cord injured rats
Abstract

•Bone loss occurs rapidly and consistently after the spinal cord injury.•Photobiomodulation is effective in reducing post-injury inflammatory processes.•Photobiomodulation accelerated the process of bone repair in rats with SCI.

Bone loss occurs rapidly and consistently after the occurrence of a spinal cord injury (SCI), leading to a decrease in bone mineral density (BMD) and a higher risk of fractures. In this context, the stimulatory effects of low level laser therapy (LLLT) also known as photobiomodulation (PBM) have been highlighted, mainly due to its osteogenic potential. The aim of the present study was to evaluate the effects of LLLT on bone healing using an experimental model of tibial bone defect in SCI rats. Twenty-four female Wistar rats were randomly divided into 3 groups: Sham group (SG), SCI control group (SC) and SCI laser treated group (SL). Two weeks after the induction of the SCI, animals were submitted to surgery to induce a tibial bone defect. Treatment was performed 3 days a week, for 2 weeks, at a single point over the area of the injury, using an 808 nm laser (30 mW, 100 J/cm2; 0.028 cm2, 1.7 W/cm², 2.8 J). The results of the histological and morphometric evaluation demonstrated that the SL group showed a larger amount of newly formed bone compared to the SC group. Moreover, a significant immunoexpression of runt-related transcription factor 2 (RUNX2) was observed in the SL group. There was no statistical difference in the biomechanical evaluation. In conclusion, the results suggest that LLLT accelerated the process of bone repair in rats with complete SCI.

Keywords
Low level laser therapy; Spinal cord injury; Bone; Rats
First Page Preview
Low level laser therapy accelerates bone healing in spinal cord injured rats
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us
Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 159, June 2016, Pages 179–185
Authors
, , , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us