fulltext.study @t Gmail

Azido carbonyl compounds as DNA cleaving agents

Paper ID Volume ID Publish Year Pages File Format Full-Text
29503 44415 2012 10 PDF Available
Title
Azido carbonyl compounds as DNA cleaving agents
Abstract

Irradiation of azido carbonyl compounds using UV light (⩾310 nm) produced triplet alkyl nitrenes and aroyl radicals, which resulted in efficient cleavage of single strand DNA at pH 7.0. DNA cleaving ability of azido carbonyl compounds was found to be dependent on its concentration and substituents on its aromatic ring. Further, newly synthesized naphthalene based azido carbonyl compounds showed DNA cleavage ability at longer wavelength of UV light (⩾350 nm) and also binding studies revealed that they bind to ct-DNA by weak intercalation mode.

Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Azido carbonyl compounds showed efficient DNA cleavage upon photo irradiation. ► DNA cleaving ability of azido carbonyls were dependent on their structure. ► Among azido carbonyls, β azido carbonyls showed better DNA cleaving ability. ► Naphthalene based azido carbonyls can bind to ct-DNA via intercalation mode.

Keywords
Photoinduced DNA cleavage; Azido carbonyl compound; Triplet alkyl nitrene; Aroyl radical; DNA binding
First Page Preview
Azido carbonyl compounds as DNA cleaving agents
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us
Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 115, 3 October 2012, Pages 25–34
Authors
, , , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us