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Persistent DNA binding, cleavage performance and eco-friendly catalytic nature of novel complexes having 2-aminobenzophenone precursor

Paper ID Volume ID Publish Year Pages File Format Full-Text
29515 44416 2016 11 PDF Available
Title
Persistent DNA binding, cleavage performance and eco-friendly catalytic nature of novel complexes having 2-aminobenzophenone precursor
Abstract

•Developing novel therapeutic tools for the medical treatment•Octahedral geometrical arrangements of the mixed ligand metal(II) complexes•Synthesis of persistent intercalators•Developing better chemical nuclease activators•Exhibiting eco-friendly potential catalytic performance

This paper describes the synthesis of four novel bidentate metal(II) complexes having 2-aminobenzophenone precursor and a co-ligand (anthranilic acid). They are characterized by the usual spectral and analytical data. They adopt octahedral geometrical arrangements around the metal ions which have been confirmed by electronic absorption data. Moreover, the EPR study of Cu(II) complex has provided supportive evidence to the conclusion drawn on the basis of electronic spectrum and magnetic moment value. Powder XRD and SEM studies show that all the complexes are microcrystalline with homogenous morphology. The interaction of these complexes with CT-DNA has been explored by UV-absorption, fluorescence, viscosity, CV and CD techniques which reveal that the complexes could bind to CT-DNA through intercalation. The oxidative cleavage of the metal complexes with pBR322 DNA has also been investigated by gel electrophoresis. Moreover, the antimicrobial bustle shows that all metal chelates have superior activity than the free Schiff base ligand. The catalytic activity of the complexes has been evaluated towards the oxidation of aniline. All the complexes exhibit significant catalytic activity. Among them Cu(II) complex exhibits better catalytic activity than others. This catalytic process occurs at room temperature and it proceeds in water medium which suggests that this is an eco-friendly process.

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Keywords
UV-absorption; Fluorescence; Antimicrobial activity; Oxidative cleavage; Catalytic activity
First Page Preview
Persistent DNA binding, cleavage performance and eco-friendly catalytic nature of novel complexes having 2-aminobenzophenone precursor
Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 156, March 2016, Pages 11–21
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering