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In vitro anticancer potential of BaCO3 nanoparticles synthesized via green route

Paper ID Volume ID Publish Year Pages File Format Full-Text
29517 44416 2016 6 PDF Available
Title
In vitro anticancer potential of BaCO3 nanoparticles synthesized via green route
Abstract

•Green synthesis is a simple, rapid, clean, inexpensive and eco-friendly.•BaCO3 NPs were synthesized using an aqueous extract of Mangifera indica seed.•Nanoparticles are characterized using FTIR, XRD, HR-TEM, EDX, SAED and XPS.•BaCO3 NPs are potential for anticancer activity in vitro.

Green synthesis of nanoparticles is a growing research area because of their potential applications in nanomedicine. Barium carbonate nanoparticles (BaCO3 NPs) were synthesized using an aqueous extract of Mangifera indica seed as a reducing agent. These particles were characterized by Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), Transmission electron microscopy (TEM), selected area electron diffraction (SAED), Energy-dispersive-X-ray (EDX) and X-ray photoelectron spectroscopy (XPS) analysis. HR-TEM images are confirmed that green synthesized BaCO3 NPs have spherical, triangular and uneven shapes. EDX analysis confirmed the presence of Ba, C and O. The peaks at 2θ of 19.45, 23.90, 24.29, 27.72, 33.71, 34.08, 34.60, 41.98, 42.95, 44.18, 44.85, and 46.78 corresponding to (110), (111), (021), (002), (200), (112), (130), (221), (041), (202), (132) and (113) showed that BaCO3 NPs average size was ~ 18.3 nm. SAED pattern confirmed that BaCO3 NPs are crystalline nature. BaCO3 NPs significantly inhibited cervical carcinoma cells, as evidenced by cytotoxicity assay. Immunofluorescence and fluorescence assays showed that BaCO3 NPs increased the expression and activity of caspase-3, an autocatalytic enzyme that promotes apoptosis. According to the results, green synthesis route has great potential for easy, rapid, inexpensive, eco-friendly and efficient development of novel multifunctional nanoparticles for the treatment of cancer.

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Keywords
Green synthesis; Mangifera indica; BaCO3 nanoparticles; Caspase-3; Cytotoxicity
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In vitro anticancer potential of BaCO3 nanoparticles synthesized via green route
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 156, March 2016, Pages 29–34
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us