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Synthesis, interactions, molecular structure, biological properties and molecular docking studies on Mn, Co, Zn complexes containing acetylacetone and pyridine ligands with DNA duplex

Paper ID Volume ID Publish Year Pages File Format Full-Text
29571 44422 2016 11 PDF Available
Title
Synthesis, interactions, molecular structure, biological properties and molecular docking studies on Mn, Co, Zn complexes containing acetylacetone and pyridine ligands with DNA duplex
Abstract

•Structural characterizations of complex (2) [Co(acac)2(py)·H2O]•DNA/protein interaction studies of complexes (1–3)•Molecular docking studies of complexes (1–3)•Cytotoxic activity of complexes (1–3) against MCF-7

Three metal complexes (1–3) of the type [Mn(acac)2(py)·H2O] (1), [Co(acac)2(py)·H2O] (2) and [Zn(acac)2(py)·H2O] (3), [Where acac = acetylacetone, py = pyridine] were synthesized and characterized by spectral (UV–vis, FT-IR, ESI-mass) analysis. The structure of complex 2 has been determined by single crystal X-ray diffraction studies and the configuration of ligand-coordinated to metal(II) ion was well described as distorted octahedral coordination geometry. The interaction of the complexes with CT-DNA has been explored by absorption, fluorescence, circular dichromism spectroscopy, viscosity measurements and molecular docking studies. The intrinsic binding constant Kb of complexes 1–3 with CT-DNA obtained from UV–vis absorption spectral studies were 2.1 × 104, 2.1 × 105 and 1.98 × 104 M− 1, respectively, which revealed that the complexes could interact with CT-DNA through groove binding. The results indicated that the complexes (1–3) were able to bind to DNA with different binding affinity, in the order: 2 > 1 > 3. The interaction of the compounds with bovine serum albumins were also investigated using fluorescence methods and the gel electrophoresis assay demonstrates weak cleavage ability of the pBR322 plasmid DNA in the presence of the metal complexes (1–3) with various activators. Further, the in vitro cytotoxic effect of the complexes were examined on cancerous cell line, with human breast cancer cells MCF-7.

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Keywords
MnII; CoII; ZnII complexes; DNA/protein interaction; Molecular modeling; Cytotoxic activities
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Synthesis, interactions, molecular structure, biological properties and molecular docking studies on Mn, Co, Zn complexes containing acetylacetone and pyridine ligands with DNA duplex
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 160, July 2016, Pages 110–120
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us