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Benzochloroporphyrin derivative photosensitizer-mediated photodynamic therapy for Ewing sarcoma

Paper ID Volume ID Publish Year Pages File Format Full-Text
29579 44422 2016 7 PDF Available
Title
Benzochloroporphyrin derivative photosensitizer-mediated photodynamic therapy for Ewing sarcoma
Abstract

•The photosensitivity of BCPD-18 on Ewing Sarcoma has been tested both in vitro and in vivo.•Apoptosis and cell cycle arrest were detected after BCPD-18 mediated PDT.•Expression of Bax increased while expression of Bcl-2 decreased after in vivo BCPD-18 mediated PDT.

In this study, we evaluated the photodynamic efficacy of a new photosensitizer, benzochloroporphyrin derivative 18 (BCPD-18), in Ewing sarcoma. We found that BCPD-18 decreased the viability of TC-71 cells irradiated by 670 nm laser in a concentration dependent manner. We also observed cells undergoing apoptosis as well as cell cycle arrest at the G2M phase after BCPD–18-mediated photodynamic therapy (BCPD-PDT). In addition, in vivo study (subcutaneous and orthotopic models) showed that BCPD-PDT reduced tumor size, tumor weight and tumor-bearing leg weight. After PDT, apoptosis was shown in vivo. Bax expression was increased, and Bcl-2 expression was decreased. This study provides evidence that BCPD-18 could probably be a useful photosensitizer in PDT for Ewing sarcoma.

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Keywords
Photodynamic therapy; Ewing sarcoma; Benzochloroporphyrin derivatives
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 160, July 2016, Pages 178–184
Authors
, , , , , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us