fulltext.study @t Gmail

Synthesis, characterization of new copper (ii) Schiff base and 1,10 phenanthroline complexes and study of their bioproperties

Paper ID Volume ID Publish Year Pages File Format Full-Text
29583 44422 2016 8 PDF Available
Title
Synthesis, characterization of new copper (ii) Schiff base and 1,10 phenanthroline complexes and study of their bioproperties
Abstract

•Cu(II) Schiff base complexes are better DNA intercalators in cancer therapy.•Hydrolytic pathway usually depends on the lewis acidity of the central metal ion.•Liposolubility is an important factor for controlling antimicrobial activity.

Three mononuclear Cu(II) complexes [Cu(naph-phe)phen] (1), [Cu(naph-tyr)(phen)] (2) and [Cu(naph-trp)(phen)] (3) were synthesized, characterized and their biological properties were studied. Complexes 1, 2, 3 exhibit square pyramidal geometry where Schiff base acts as a binegative tridentate ONO donor ligand and phen acts as NN donor ligand. CT-DNA binding studies revealed that the complexes bind through intercalative mode and show good binding propensity. The hydrolytic DNA cleavage activity of these complexes has been studied using gel electrophoresis. The DNA binding and cleavage affinities decrease in the order of 3 > 2 > 1. The in-vitro antimicrobial activities of the complexes were also studied.

Graphical Abstract[Cu(II)(naph-phe)phen] (1), [Cu(II)(naph-tyr)phen] (2)and [Cu(II)(naph-trp)phen] (3) were synthesized, characterized and their DNA binding, cleavage and antibacterial properties were studied.Figure optionsDownload full-size imageDownload as PowerPoint slide

Keywords
phen, 1,10 phenanthroline; CT-DNA, calf thymus DNA; Tris, Tris(hydroxymethyl)aminomethane; EB, ethidium bromide; UV–vis, UV–visible; 1, [Cu(II)(naph-phe)(phen)]; 2, [Cu(II)(naph-tyr)(phen)]; 3, [Cu(II)(naph-trp)(phen)]Cu(II) Schiff bases; DNA binding, cle
First Page Preview
Synthesis, characterization of new copper (ii) Schiff base and 1,10 phenanthroline complexes and study of their bioproperties
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us
Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 160, July 2016, Pages 217–224
Authors
, , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us