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Photodynamic effects of porphyrin–polyamine conjugates in human breast cancer and keratinocyte cell lines

Paper ID Volume ID Publish Year Pages File Format Full-Text
29671 44429 2011 6 PDF Available
Title
Photodynamic effects of porphyrin–polyamine conjugates in human breast cancer and keratinocyte cell lines
Abstract

Porphyrin-polyamine conjugates bearing two (cis or trans position) or four spermidine or spermine units were synthesized. We studied the photostability, the hydrophilic/lipophilic balance of porphyrin–polyamine derivatives and the production of singlet oxygen. All these compounds possess physicochemical features required for their use in PDT. Then, we investigated the photocytotoxic efficacy of these porphyrin–polyamine derivatives and the cell death pathway implicated. All compounds appear to be more efficient than Photofrin® to induce HaCat and MCF7 cell death, essentially by apoptosis. Collectively, these data show that porphyrin-polyamine conjugates could be promising phototherapeutic agents.

► Design and synthesis of a new series of porphyrin-polyamine conjugates. ► Photophysical and photochemical properties of these porphyrin similar to Photofrin®. ► Better phototoxic efficiency of porphyrin polyamine derivatives than Photofrin®. ► Compounds essentially induce apoptosis with a minor fraction of necrosis. ► Porphyrin–polyamine conjugates could be promising phototherapeutic agents.

Keywords
Photodynamic therapy; Porphyrin; Polyamines; Apoptosis; Necrosis
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Photodynamic effects of porphyrin–polyamine conjugates in human breast cancer and keratinocyte cell lines
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 103, Issue 3, 2 June 2011, Pages 201–206
Authors
, , , , , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us