Nanosized ZSM-5 will improve photodynamic therapy using Methylene blue
•Modification of ZSM-5 nanozeolite by Methylene blue and Polyethylene Glycol.•The absorption peak of modified nanostructure remains in therapeutic window.•Significant production of singlet oxygen onto modified nanozeolite under red laser.•The modified nanozeolite revealed outstanding photodynamic treatment potential.
Nowadays, nanotechnology is growing to improve Photodynamic Therapy and reduce its side effects. In this research, the synthesized co-polymeric Zeolite Secony Mobile-5 (ZSM-5) was employed to modify Methylene Blue (MB) for these reasons. UV–Visible, FTIR, XRD analysis and SEM images were used to investigate obtained nanostructure. The crystal size for these nanostructures were determined 75 nm and maximum adsorption capacity of MB in the nanostructure was estimated 111 (mg g−1). Also, the role of Polyethylene Glycol (PEG) was studied as a capable non-toxic polymeric coating to overcome biological barriers. Moreover, potential of singlet oxygen production of the synthesized nanostructure was compared with MB and ZSM-5 nanoparticles control samples. Synthesized nanodrugs show impressive light induced singlet oxygen production efficiency.
Graphical abstractZSM-5 Nanoparticles modified with PEG and Methylene Blue are illuminated by red laser source as a photo-oxidation process. High singlet oxygen production efficiency observed compared to the results obtained from MB and ZSM-5. These nanostructures can be employed in modern photodynamic therapy based on their capability to overcome biological barriers and their significant photo-toxicity.Figure optionsDownload full-size imageDownload as PowerPoint slide
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 148, July 2015, Pages 107–112