fulltext.study @t Gmail

Evaluation of functional characteristics of preactivated thiolated chitosan as potential therapeutic agent for dry mouth syndrome

Paper ID Volume ID Publish Year Pages File Format Full-Text
297 23 2015 9 PDF Available
Title
Evaluation of functional characteristics of preactivated thiolated chitosan as potential therapeutic agent for dry mouth syndrome
Abstract

PurposeThe objective of this study was to investigate preactivated thiomers for their potential in the treatment of dry mouth syndrome.MethodsChitosan–thioglycolic–mercaptonicotinamide conjugates (chitosan–TGA–MNA) were synthesized by the oxidative S–S coupling of chitosan–thioglycolic acid (chitosan–TGA) with 6-mercaptonicotinamide (MNA). Test disks were compressed out of unmodified chitosan, chitosan–TGA (thiomers) and chitosan–TGA–MNA conjugates to investigate cohesive properties, cytotoxicity assays and mucoadhesion studies.ResultsImmobilizing the MNA achieved higher swelling and cohesive properties of chitosan–TGA–MNA conjugates compared to unmodified chitosan. Rotating cylinder studies displayed a 3.1-fold improvement of mucoadhesiveness of chitosan–TGA–MNA conjugates compared to thiolated polymers. Findings in tensile strength were in good agreement with rotating cylinder ones. Furthermore, preactivated thiomers exhibit higher stability. All conjugates were found non-toxic against Caco-2 cells.ConclusionPreactivated thiolated chitosan could be a promising system for the treatment of dry mouth syndrome where mucosa requires lubrication and mucoadhesiveness.

Graphical abstractFigure optionsDownload full-size imageDownload high-quality image (76 K)Download as PowerPoint slide

Keywords
Thiomers; Chitosan–thioglycolic acid; Mercaptonicotinamide; Preactivated thiomers; Dry mouth syndrome
First Page Preview
Evaluation of functional characteristics of preactivated thiolated chitosan as potential therapeutic agent for dry mouth syndrome
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us
Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 21, 15 July 2015, Pages 123–131
Authors
, , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us