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Effect of tetracycline and UV radiation on melanization and antioxidant status of melanocytes

Paper ID Volume ID Publish Year Pages File Format Full-Text
29703 44431 2015 6 PDF Available
Title
Effect of tetracycline and UV radiation on melanization and antioxidant status of melanocytes
Abstract

•Tetracycline and/or UVA radiation decreased melanocytes viability.•Tetracycline stimulates melanogenesis in melanocytes exposed to UVA radiation.•UVA radiation enhances oxidative stress in melanocytes treated with tetracycline.

Tetracycline is a semisynthetic antibiotic and is used in several types of infections against both gram-positive and gram-negative bacteria. This therapy is often associated with phototoxic reactions that occur after exposure to UV radiation and lead to photo-onycholysis, pseudoporphyria, solar urticaria and the fixed drug eruption in the skin. The phototoxic reactions may be related to the melanin content which, on one side may bind drugs – leading to their accumulation, and on the other side, they have photoprotective and antioxidant properties.In this study the effect of tetracycline and UVA irradiation on cell viability, biosynthesis of melanin and antioxidant defense system in cultured normal human epidermal melanocytes (HEMn-DP) was analyzed. The viability of the cells treated with tetracycline and exposed to UVA radiation decreased in a drug concentration-dependent manner. At the same time, the induction of the melanization process was observed. The significant alterations in antioxidant defense system, on the basis of changes in SOD, CAT and GPx activities, were stated. The obtained results may give explanation for the phototoxic effects of tetracycline therapy observed in skin cells exposed to UVA radiation.

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Effect of tetracycline and UV radiation on melanization and antioxidant status of melanocytes
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 148, July 2015, Pages 168–173
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us