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Improvement in UV protection retention capability and reduction in skin penetration of benzophenone-3 with mesoporous silica as drug carrier by encapsulation

Paper ID Volume ID Publish Year Pages File Format Full-Text
29716 44431 2015 7 PDF Available
Title
Improvement in UV protection retention capability and reduction in skin penetration of benzophenone-3 with mesoporous silica as drug carrier by encapsulation
Abstract

•Mesoporous silica encapsulated BP-3 UV-filter (BES-2) was successfully prepared.•The BES-2 containing sunscreen exhibited ca. 2 times improvement in SPF.•The BES-2 containing sunscreen reduced ca. 3 times for skin permeation of BP-3.

In this study, various amounts of benzophenone-3 (BP-3), a solid-type of organic UV-filter, were encapsulated in mesoporous silica (MS) to form the BP-3 encapsulated by MS UV-filters (BESs), BES-1 and BES-2, via in-situ sol–gel process. The characterization of BESs was completed using Fourier transform infrared (FTIR) spectroscopy, thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC). The results showed that of the BES filters, BES-2 containing emulsion (BES-2-E) exhibited about 2 times and 1.64 times higher SPF and erythemal UV-A PF values, respectively, and after 3 months about 7–8 times higher protection retention capability than the free BP-3 containing emulsion (BP-3-E). Moreover, the result of the in vitro skin penetration test using Franz glass diffusion cell indicated that the skin permeation of BP-3 from BESs was about 3 times lower than from BP-3-E. This property is particularly important for sunscreens because the amount of sunscreen penetration inside the stratum corneum directly correlates to its UV protection ability, and consequently its ability to reduce phototoxic and photo-allergic reactions that are damaging to the skin. The results of this study demonstrated the potential of as-prepared BES-2 as a UV-filter for cosmetic products.

Graphical abstract1. The Franz glass diffusion cell tests show about 3 times lower skin permeation of BP-3 from BES-2-E than from BP-3-E, largely improving the prevention of cutaneous reaction and systemic absorption. 2. The changes in SPF reduction percentage with time show that BES-2-E exhibited about 7–8 times higher UV protection retention capability in 3 months compared to BP-3-E, indicating that the shelf life of BES-2-E was much higher than that of BP-3-E.Figure optionsDownload full-size imageDownload as PowerPoint slide

Keywords
Benzophenone-3; Mesoporous silica; Organic UV-filter; Drug carrier; In vitro release and skin penetration
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Improvement in UV protection retention capability and reduction in skin penetration of benzophenone-3 with mesoporous silica as drug carrier by encapsulation
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 148, July 2015, Pages 277–283
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us