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Fluorescence in neurosurgery: Its diagnostic and therapeutic use. Review of the literature

Paper ID Volume ID Publish Year Pages File Format Full-Text
29719 44431 2015 8 PDF Available
Title
Fluorescence in neurosurgery: Its diagnostic and therapeutic use. Review of the literature
Abstract

•5-ALA-fluorescence guided resection improves overall survival.•5-ALA in photodynamic therapy is a promising treatment option.•Intraoperative ICG angiography might be of value for vascular pathologies.•Fluorescein fluorescence is less specific for pathologies.

Fluorescent agents, e.g. 5-aminolevulinic acid (5-ALA), fluorescein and indocyanine green (ICG) are in common use in neurosurgery for tumor resection and neurovascular surgery. Protoporphyrine IX (PPIX) as major metabolite of 5-ALA is a strong fluorescent substance accumulated within malignant glioma tissue and a very sensitive and specific tool for visualizing high grade glioma tissue during surgery. Furthermore, 5-ALA or rather PPIX also offers an intratumoral therapeutic option stimulated by laser light in specific wavelength. Fluorescein was demonstrated to show similar fluorescent reactions in neurosurgery, but is controversial in its use, especially in high grade tumor surgery. Intraoperative angiography during resection of arterio-venous malformations, extracranial–intracranial-bypass or aneurysm surgery is supported by ICG fluorescence. Generally ICG will provide beneficial information for both, exposure of the pathology and illustration of healthy structures. This manuscript shows an overview of the literature focussing fluorescence in neurosurgery.

Keywords
5-aminolevulinic acid; Indocyanin green; Fluorescein; Brain tumors; Intraoperative angiography
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Fluorescence in neurosurgery: Its diagnostic and therapeutic use. Review of the literature
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 148, July 2015, Pages 302–309
Authors
, , , , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
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Any Questions? feel free to contact us