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Synthesis, spectral, structural characterization and biological investigation of m-Xylylenediaminium-bis (p-toluenesulfonate) monohydrate

Paper ID Volume ID Publish Year Pages File Format Full-Text
29725 44431 2015 8 PDF Available
Title
Synthesis, spectral, structural characterization and biological investigation of m-Xylylenediaminium-bis (p-toluenesulfonate) monohydrate
Abstract

•Molecular structure of the compound was confirmed by single crystal X-ray diffraction technique.•The compound showed good antimicrobial activity.•The compound interacts with CT-DNA, through intercalatively.•The compound possesses valuable antioxidant property against DPPH, OH and ABTS radicals.•The complex showed significant cytotoxicity activity against MCF-7 cancer cell line.

Novel organic charge transfer complex, m-xylylenediaminium-bis (p-toluenesulfonate) monohydrate (XDPTS) have been synthesized and crystallized to the triclinic system with space group P-1 and the lattice parameters obtained are a = 9.9265(7) Å, b = 9.9676(6) Å, c = 13.4948(10) Å, α = 71.95(6)°, β = 77.02(6)°, γ = 76.851(5)°. The synthesized complex structure was confirmed by IR, 1H NMR and 13C NMR spectral analysis. Pharmacology activities of charge transfer complex were evaluated through antimicrobial, DNA binding/cleavage, antioxidant and cytotoxicity studies. The results reveal that the compound shows good antimicrobial activity against various antibacterial and antifungal species. The DNA interaction indicated that the compound could interact with DNA through intercalation, which is further confirmed by viscosity measurements. The compound should have weak to moderate capacity of scavenging with DPPH, Hydroxyl and ABTS radicals. The cytotoxicity has been evaluated by MTT assay method against MCF-7 cancer cell line.

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Keywords
Crystal structure; Antimicrobial; DNA binding/cleavage; Antioxidant; Cytotoxicity
First Page Preview
Synthesis, spectral, structural characterization and biological investigation of m-Xylylenediaminium-bis (p-toluenesulfonate) monohydrate
Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 148, July 2015, Pages 358–365
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering