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Effects of blue light irradiation on human dermal fibroblasts ☆

Paper ID Volume ID Publish Year Pages File Format Full-Text
29743 44434 2011 8 PDF Available
Title
Effects of blue light irradiation on human dermal fibroblasts ☆
Abstract

Previous studies have reported that separately from UV-radiation also blue light influences cellular physiology in different cell types. However, little is known about the blue light action spectrum. The purpose of this study was to investigate effects of blue light at distinct wavelengths (410, 420, 453, 480 nm) emitted by well defined light-emitting-diodes on viability, proliferation and antioxidative capacity of human dermal fibroblasts. We found that irradiation with blue light (410, 420 nm) led to intracellular oxidative stress and toxic effects in a dose and wavelength dependent manner. No toxicity was observed using light at 453 nm and 480 nm. Furthermore, blue light (410, 420, 453 nm) at low doses reduced the antioxidative capacity of fibroblasts. At non-toxic doses, irradiations at 410, 420 and 453 nm reduced proliferation indicating a higher susceptibility of proliferating fibroblasts to blue light. Our results show that blue light at different wavelengths may induce varying degrees of intracellular oxidative stress with different physiological outcome, which could contribute to premature skin photoaging. On the other hand, the use of blue light due to its antiproliferative and toxic properties may represent a new approach in treatment and prevention of keloids, hypertrophic scars and fibrotic skin diseases.

► We have investigated the effects of blue light on human dermal fibroblasts. ► We used novel Light emitting diodes (LED) emitting at 410,420, 453 and 480 nm. ► Blue light induced wavelength and dose dependent toxicity and oxidative stress. ► Longer wavelengths (453, 480 nm) did not show toxicity but effects on proliferation. ► Possible therapeutical use in the treatment of hypertrophic scars and keloids.

Keywords
Fibroblasts; Visible light; Blue light
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Effects of blue light irradiation on human dermal fibroblasts ☆
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 103, Issue 2, 3 May 2011, Pages 118–125
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us