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The protective function of hydrogen sulfide for lysozyme against riboflavin-sensitized photo-oxidation

Paper ID Volume ID Publish Year Pages File Format Full-Text
29751 44434 2011 6 PDF Available
Title
The protective function of hydrogen sulfide for lysozyme against riboflavin-sensitized photo-oxidation
Abstract

Hydrogen sulfide is the third endogenous signaling gasotransmitter, following nitric oxide and carbon monoxide. Recent studies showed that hydrogen sulfide could alleviate many diseases which were related to the oxidative damage of tissues. It reminded us that hydrogen sulfide might serve as an antioxidant to reduce oxidative pressure. This study showed that hydrogen sulfide protected lysozyme from photo-oxidation induced by riboflavin (RF). Laser flash photolysis was used to explore the mechanisms of antioxidant activity of hydrogen sulfide. The scavenging effects of hydrogen sulfide on the triplet state of riboflavin (3RF*) and radicals of tryptophan and tyrosine (TyrO and TrpN) were attributed to the protection of lysozyme from photo-oxidation. The results suggested that hydrogen sulfide could serve as an antioxidant in alleviation of oxidative pressure.

► Hydrogen sulfide was proved to protect lysozyme from photo-oxidation induced by riboflavin. ► Hydrogen sulfide can scavenge the triplet state of riboflavin. ► Hydrogen sulfide can accelerate the decay of radicals of tryptophan and tyrosine. ► Hydrogen sulfide was inferred to serve as an antioxidant in alleviation of oxidative pressure.

Keywords
Riboflavin; Hydrogen sulfide; Laser flash photolysis; Oxidative stress; Free radical
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The protective function of hydrogen sulfide for lysozyme against riboflavin-sensitized photo-oxidation
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 103, Issue 2, 3 May 2011, Pages 186–191
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us