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Comment on “Binding of alkaloid harmalol to DNA: Photophysical and calorimetric approach”

Paper ID Volume ID Publish Year Pages File Format Full-Text
29757 44436 2014 3 PDF Available
Title
Comment on “Binding of alkaloid harmalol to DNA: Photophysical and calorimetric approach”
Abstract

•Evidence on the incorrect assignment of acid-base equilibria of harmalol, by Sarkar and Bhadra is provided.•Results are compared with controversial data reported in the literature (J. Photochem. Photobiol. B: Biol. 130 (2014) 272).•In the pH range 2–13 harmalol shows two acid-base equilibria with pKa1 and pKa2 values of 8.5 and 11.2, respectively.•Absorption coefficient values (ε) reported by Sarkar et. al. are overestimated (∼2.5 higher than the corresponding ε values).

The present manuscript is a comment on the article entitled “Binding of alkaloid harmalol to DNA: Photophysical and calorimetric approach” by Sarita Sarkar and Kakali Bhadra (2014) [1]. In their article, the authors reported the chemical structure as well as the absorption spectra of harmalol at different pH. On the bases of the previous publications and our own present results, the assignment of the number of the acid-base species and the corresponding pKa values, as well as the chemical structure for each species are erroneous. These facts have strong effect on the conclusions reached by the authors, in terms of the interaction with DNA.

Keywords
Harmalol; β-carbolines; Acid-base equilibria
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Comment on “Binding of alkaloid harmalol to DNA: Photophysical and calorimetric approach”
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 136, 5 July 2014, Pages 26–28
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
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Price was $35.95
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