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Melatonin plays a critical role in inducing B lymphocyte proliferation of the bursa of Fabricius in broilers via monochromatic lights

Paper ID Volume ID Publish Year Pages File Format Full-Text
29779 44440 2015 6 PDF Available
Title
Melatonin plays a critical role in inducing B lymphocyte proliferation of the bursa of Fabricius in broilers via monochromatic lights
Abstract

•The monochromatic green light enhanced B lymphocyte proliferation in young broilers.•Melatonin plays a critical role on monochromatic GL enhanced B cell proliferation.•The antioxidative pathway involved in MEL mediating GL induced B cell proliferation.

To study the role of melatonin in the monochromatic light-induced B lymphocyte proliferation of bursa, a total of 360 newly hatched broilers, including intact, sham-operated, and pinealectomized groups, were exposed to blue light (BL), green light (GL), red light (RL) and white light (WL) from a light-emitting diode system for 14d. Both in vivo and in vitro studies showed that the percentage of proliferating cell nuclear antigen (PCNA)-immunoreactive lymphocytes and the lymphocyte proliferation in response to lipopolysaccharide in the bursa of broilers in the GL intact group was the highest values among the different intact groups with altered plasma melatonin levels. Additionally, the superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities and total antioxidant capability (T-AOC) were the highest, whereas malondialdehyde (MDA) content and inducible nitric oxide synthase (iNOS) expression were significantly decreased in the GL intact group. After pinealectomy, the levels of SOD, GSH-Px and T-AOC decreased remarkably in the various light-treatment groups, whereas the MDA content and iNOS expression significantly increased. The administration of exogenous melatonin (250 pg/mL) in vitro also significantly enhanced the bursal B lymphocyte proliferation. These findings suggest that GL illumination effectively elevates the antioxidative capacity to promote B lymphocyte proliferation of bursa in young broilers, which might depend on enhanced melatonin secretion.

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Melatonin plays a critical role in inducing B lymphocyte proliferation of the bursa of Fabricius in broilers via monochromatic lights
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 142, January 2015, Pages 29–34
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us