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Synthesis of phthalocyanine conjugates with gold nanoparticles and liposomes for photodynamic therapy

Paper ID Volume ID Publish Year Pages File Format Full-Text
29813 44441 2012 10 PDF Available
Title
Synthesis of phthalocyanine conjugates with gold nanoparticles and liposomes for photodynamic therapy
Abstract

The efficiency of [2,9,17,23-tetrakis-(1,6-hexanedithiol)phthalocyaninato]zinc(II) as a photodynamic therapy (PDT) agent was investigated. This compound belongs to the second generation of photosensitizers currently tested for the cellular photo-damage of cancer cells. The production of reactive oxygen species (ROS) and phototoxicity of the photosensitizer were assessed. Healthy fibroblast cells and breast cancer (MCF-7) cells were treated with either free phthalocyanine or phthalocyanine bound to either gold nanoparticles or encapsulated in liposomes. Cell viability studies showed the optimum phototoxic effect on non-malignant cells to be 4.5 J cm−2. The PDT effect of the liposome bound phthalocyanine showed extensive damage of the breast cancer cells. Gold nanoparticles only showed a modest improvement in PDT activity.

Graphical abstract[2,9,17,23-Tris-(1,6-hexanedithiol)phthalocyaninato]zinc(II) exhibit good photodynamic therapy (PDT) activity towards breast cancer cells when attached to the liposome, gold nanoparticles showed only moderate improvement of PDT activity.Figure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Zinc phthalocyanine tetra substituted with hexanedithiol was synthesized. ► The complex was tested for photodynamic therapy towards cancer cells. ► The activity was improved in liposomes.► Gold nanoparticles only showed moderate improvement.

Keywords
Phthalocyanine; Gold nanoparticles; Liposome; Photodynamic therapy
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Synthesis of phthalocyanine conjugates with gold nanoparticles and liposomes for photodynamic therapy
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 107, 6 February 2012, Pages 35–44
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us