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Synthesis, structure, DNA-binding properties and antioxidant activity of a nickel(II) complex with bis(N-allylbenzimidazol-2-ylmethyl)benzylamine

Paper ID Volume ID Publish Year Pages File Format Full-Text
29816 44441 2012 8 PDF Available
Title
Synthesis, structure, DNA-binding properties and antioxidant activity of a nickel(II) complex with bis(N-allylbenzimidazol-2-ylmethyl)benzylamine
Abstract

A V-shape ligand bis(N-allylbenzimidazol-2-ylmethyl)benzylamine (babb) and its nickel complex, [Ni(babb)2](pic)2 (pic = picrate), have been synthesized and characterized by physico-chemical and spectroscopic methods. Single-crystal X-ray revealed that the coordination sphere around Ni(II) is distorted octahedral with a N6 ligand set, in which six nitrogen atoms were afforded by two tridentate ligand babb. The DNA-binding properties of the free ligand babb and Ni(II) complex have been investigated by electronic absorption, fluorescence, and viscosity measurements. The results suggest that babb and Ni(II) complex both bind to DNA via an intercalative binding mode, and the affinity for DNA is more strong in case of Ni(II) complex when compared with babb. The intrinsic binding constants (Kb) of the Ni(II) complex and ligand with DNA were 3.65 × 104 M−1 and 2.26 × 103 M−1, respectively. Additionally, Ni(II) complex also exhibited potential antioxidant properties in vitro studies.

Graphical abstractA V-shape ligand babb and its nickel(II) complex, [Ni(babb)2](pic)2 were synthesized and characterized. The DNA binding properties and antioxidation were also investigated.Figure optionsDownload full-size imageDownload as PowerPoint slideHighlights► A V-shape ligand babb and Ni(II) complex have been synthesized and characterized. ► The ligand babb and Ni(II) complex bind to DNA in an intercalation mode. ► The Ni(II) complex has the preferable ability to scavenge hydroxyl radical.

Keywords
Benzimidazole; Nickel(II) complex; Crystal structure; DNA-binding property; Antioxidant property
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Synthesis, structure, DNA-binding properties and antioxidant activity of a nickel(II) complex with bis(N-allylbenzimidazol-2-ylmethyl)benzylamine
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 107, 6 February 2012, Pages 65–72
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
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