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Photodynamic therapy (PDT): A short review on cellular mechanisms and cancer research applications for PDT

Paper ID Volume ID Publish Year Pages File Format Full-Text
29820 44442 2009 8 PDF Available
Title
Photodynamic therapy (PDT): A short review on cellular mechanisms and cancer research applications for PDT
Abstract

Photodynamic therapy (PDT) has been used for many years, but it is only now becoming widely accepted and utilized. Originally it was developed as a tumor therapy and some of its most successful applications are for non-malignant diseases. This article provides a broad review of different parameters used and mechanisms instituted in PDT such as photosensitizers (PS), photochemistry and photophysics, cellular localization, cellular signaling, cell metabolism and modes of cell death that operate on a cellular level, as well as photosensitizer pharmacokinetics, biodistribution, tumor localization and modes of tumor destruction. These specific cellular mechanisms are most commonly applied in PDT and for the most part are often researched and exploited. If the combination of these specific parameters and mechanisms can be optimized within PDT it could possibly be used as a suitable alternative for the treatment and management of specific cancers.

Keywords
Photodynamic therapy; PDT mechanisms; Photosensitizers; Photochemistry; Cellular mechanisms; Tumor destruction
First Page Preview
Photodynamic therapy (PDT): A short review on cellular mechanisms and cancer research applications for PDT
Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 96, Issue 1, 17 July 2009, Pages 1–8
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering