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Charge dependent photodynamic activity of alanine based zinc phthalocyanines

Paper ID Volume ID Publish Year Pages File Format Full-Text
29833 44444 2014 10 PDF Available
Title
Charge dependent photodynamic activity of alanine based zinc phthalocyanines
Abstract

•Three alanine-based zinc phthalocyanines of differing charge were synthesized.•Charge influence the aggregation state and cellular uptake of phthalocyanines.•Charge influence the singlet oxygen generation of phthalocyanines.•Charge influence the photodynamic activity of phthalocyanines.•Electropositive ZnPc3 shows the best anticancer activity compared to the others.

In this paper, to minimize the effects of different structure, three alanine-based zinc phthalocyanines (Pcs) of differing charges were engineered and synthesized with the same basic structure. On this premise, the relationship between nature of charge and photodynamic activity was studied. Besides, further verification and explanation of some inconsistent results were also carried out. The results showed that charge can influence the aggregation state, singlet oxygen generation ability and cellular uptake of Pcs, thereby affecting their photodynamic activity. In addition, the biomolecules inside cells may interact with Pcs of differing charges, which can also influence the aggregation state and singlet oxygen generation of the Pcs, and then influence the relationship between nature of charge and photodynamic activity.

Graphical abstractCharge can influence the aggregation state, singlet oxygen generation ability and cellular uptake of phthalocyanines, thus, finally affect their photodynamic activity.Figure optionsDownload full-size imageDownload as PowerPoint slide

Keywords
Photodynamic activity; Alanine based zinc phthalocyanine; Photosensitizer; Charge; Aggregation state; Singlet oxygen
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 141, December 2014, Pages 10–19
Authors
, , , , , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us