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Synthesis, structure, DNA/BSA interaction and in vitro cytotoxic activity of nickel(II) complexes derived from S-allyldithiocarbazate

Paper ID Volume ID Publish Year Pages File Format Full-Text
29852 44444 2014 10 PDF Available
Title
Synthesis, structure, DNA/BSA interaction and in vitro cytotoxic activity of nickel(II) complexes derived from S-allyldithiocarbazate
Abstract

•New nickel(II) complexes containing S-allyldithiocarbazates were synthesized and characterized.•The squareplanar geometry of the complexes was determined by X-ray single crystal.•The complexes interact with DNA via intercalative mode and BSA interact with static interaction.•A nickel(II) complex showed high cytotoxicity to HeLa tumor cell lines.

Two nickel(II) complexes with formula NiL1 and NiL2 (HL1 = S-allyl-4-methoxybenzylidene hydrazinecarbodithioate, HL2 = S-allyl-1-napthylidenehydrazinecarbodithioate) have been synthesized and characterized by elemental analysis, FT-IR, NMR, UV–vis spectroscopy and ESI mass spectrometry. The crystal structure of complex 1 has been determined by single crystal X-ray diffractometry. Both HL1 and HL2 ligands are coordinated to the metal in thiolate form. In complexes, squareplanar geometry of the nickel is coordinated with two bidentate ligand units acting through azomethine nitrogen and thiolato sulfur atoms. To explore the potential medicinal value of the complexes with calf thymus DNA and bovine serum albumin (BSA) were studied at normal physiological conditions using fluorescence spectral techniques. The DNA binding constant values of the complexes were found in the range from 5.02 × 104, 3.54 × 104, and the binding affinities are in the following order 1 > 2. In addition, nickel complexes 1 and 2 shows better binding propensity to the bovine serum albumin (BSA) protein, giving a Ksv value 5.8 × 104, 4.47 × 104 respectively. From the oxidative cleavage of the complexes with pBR322 DNA, it is inferred that the effects of cleavage are dose-dependent. In addition, in vitro cytotoxicity of the complexes assayed against Vero and HeLa cell lines have shown higher cytotoxic activity with the lower IC50 values indicating their efficiency in killing cancer cells even at various concentrations.

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Synthesis, structure, DNA/BSA interaction and in vitro cytotoxic activity of nickel(II) complexes derived from S-allyldithiocarbazate
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 141, December 2014, Pages 176–185
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
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Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
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