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Photodynamic activity of thiophene-derived lysosome-specific dyes

Paper ID Volume ID Publish Year Pages File Format Full-Text
29875 44445 2016 7 PDF Available
Title
Photodynamic activity of thiophene-derived lysosome-specific dyes
Abstract

•TC dyes interact with HSA as indicated by UV–Vis and fluorescence measurements.•TC1 and TC2 result in efficient 1O2 generators.•TC1 and TC2 cause a rapid intracellular ROS release following light beam exposure.•TC1 compound has a considerable photo-toxic effect in human fibrosarcoma cells.

The photodynamic activity occurring through the lysosome photo-damage is effective in terms of triggered synergic effects which can avoid chemo-resistance pathways. The potential photodynamic activity of two fluorescent lysosome-specific probes was studied providing their interaction with human serum albumin, demonstrating their in vitro generation of singlet oxygen and investigating the resulted photo-toxic effect in human cancer cells.

Keywords
DPBF, 1,3-diphenylisobenzofuran; HSA, human serum albumin; lyso-PDT, photo-damage of lysosomes; mito-PDT, photo-damage of mitochondria; PDT, photodynamic therapy; PS, photosensitizer; ROS, reactive oxygen speciesThiophene dyes; Lysosomes; Photosensitizers
First Page Preview
Photodynamic activity of thiophene-derived lysosome-specific dyes
Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 158, May 2016, Pages 16–22
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering