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Review on the binding of anticancer drug doxorubicin with DNA and tRNA: Structural models and antitumor activity

Paper ID Volume ID Publish Year Pages File Format Full-Text
29907 44445 2016 6 PDF Available
Title
Review on the binding of anticancer drug doxorubicin with DNA and tRNA: Structural models and antitumor activity
Abstract

•The bindings of doxorubicin with DNA and tRNA were reviewed here.•Doxorubicin intercalation with DNA leads to its antitumor activity.•Drug binding alters DNA conformation, while does not change tRNA structure.•Research has been focused on finding effective delivery tools for doxorubicin.

In this review, we have compared the results of multiple spectroscopic studies and molecular modeling of anticancer drug doxorubicin (DOX) bindings to DNA and tRNA. DOX was intercalated into DNA duplex, while tRNA binding is via major and minor grooves. DOX–DNA intercalation is close to A-7, C-5, *C-19 (H-bonding with DOX NH2 group), G-6, T-8 and T-18 with the free binding energy of − 4.99 kcal/mol. DOX–tRNA groove bindings are near A-29, A-31, A-38, C-25, C-27, C-28, *G-30 (H-bonding) and U-41 with the free binding energy of − 4.44 kcal/mol. Drug intercalation induced a partial B to A-DNA transition, while tRNA remained in A-family structure. The structural differences observed between DOX bindings to DNA and tRNA can be the main reasons for drug antitumor activity. The results of in vitro MTT assay on SKC01 colon carcinoma are consistent with the observed DNA structural changes. Future research should be focused on finding suitable nanocarriers for delivery of DOX in vivo in order to exploit the full capacity of this very important anticancer drug.

Keywords
DOX, Doxorubicin; FTIR, Fourier transform infrared; CD, Circular dichroismDoxorubicin; DNA; tRNA; Intercalation; Groove binding; Conformation; Modeling
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Review on the binding of anticancer drug doxorubicin with DNA and tRNA: Structural models and antitumor activity
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 158, May 2016, Pages 274–279
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us