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Synthesis, spectral, structural analysis and biological evaluation of a new hydrogen-bonded charge-transfer complex: 2,3-Dimethylquinoxalinium-p-toluenesulfonate

Paper ID Volume ID Publish Year Pages File Format Full-Text
29925 44448 2014 8 PDF Available
Title
Synthesis, spectral, structural analysis and biological evaluation of a new hydrogen-bonded charge-transfer complex: 2,3-Dimethylquinoxalinium-p-toluenesulfonate
Abstract

•A new organic charge transfer crystal is prepared by slow evaporation solution growth technique.•Molecular structure of the compound was confirmed by single crystal X-ray diffraction technique.•The compound interacts with CT-DNA, through intercalatively.•The compound possesses valuable antioxidant property against DPPH radical.•The compound showed good antimicrobial activity.

Studies concentration on hydrogen-bonded charge-transfer complex formed on the reaction between basic 2,3-dimethylquinoxaline with p-toluenesulfonic acid. The crystal was characterized by IR, NMR, thermal and elemental analysis. The crystal structure was deduced by single crystal X-ray diffraction studies which indicated that cation and anion are linked through strong N+—H- - -O− type of hydrogen bond. The hydrogen bonded charge transfer crystal was screened for its pharmacology, such as Calf thymus DNA binding/cleavage, antioxidant properties. The results indicated that the compound could interact with DNA through intercalation and should have weak to moderate capacity of scavenging with DPPH. The high thermal stability is due to the molecular frame work through H-bonding interaction. The microbial activities of synthesised compound were examined against various bacteria and fungi species.

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Keywords
Charge transfer; TG–DTA; Crystal structure; DNA interaction; Antioxidant and antimicrobial activity
First Page Preview
Synthesis, spectral, structural analysis and biological evaluation of a new hydrogen-bonded charge-transfer complex: 2,3-Dimethylquinoxalinium-p-toluenesulfonate
Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 140, November 2014, Pages 20–27
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering