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Chitosan-based mucoadhesive films containing 5-aminolevulinic acid for buccal cancer’s treatment

Paper ID Volume ID Publish Year Pages File Format Full-Text
29953 44448 2014 10 PDF Available
Title
Chitosan-based mucoadhesive films containing 5-aminolevulinic acid for buccal cancer’s treatment
Abstract

•Chitosan-based films containing 5-ALA for oral application in PDT were developed.•They presented suitable characteristics for oral application.•They have promoted greater retention of 10% 5-ALA in porcine buccal mucosa.•The films after 10% 5-ALA addition had lower but suitable mucoadhesion.•Chitosan film with 10% 5-ALA is a potential delivery system for PDT in oral cavity.

Photodynamic therapy (PDT) is a relatively new method to treat various kinds of tumors, including those of the oral cavity. The topical 5-ALA-PDT treatment for tumors of the oral mucosa is preferred, since when administered systemically, there is a general photosensitization drawback in the patient. However, 5-ALA is a hydrophilic molecule and its penetration and retention is limited by topical route, including oral mucosa. We propose a topical delivery system of chitosan-based mucoadhesive film, aiming to promote greater retention of 5-ALA in tissue. The chitosan (CHT) films (4% w/w) were prepared using the solvent evaporation/casting technique. They were tested without 5-ALA resulting in permeability to water vapor (W.V.P = 2.15–8.54 g mm/(h cm2 Pa) swelling ∼300.0% (±10.5) at 4 h or 24 h and in vitro residence time >24 h for all tests. CHT films containing 10.0% (w/w) 5-ALA have resulted in average weight of 0.22 g and thickness of 0.608 mm as suitable characteristics for oral application. In the presence of CHT films both in vitro permeation and retention of 5-ALA (1.0% or 10.0%) were increased. However, 10.0% 5-ALA presented highest values of permeation and retention (∼4 and 17 times respectively, compared to propylene glycol vehicle). On the other hand, in vitro mucoadhesion of CHT films was decreased (18.2-fold and 3.1-fold) by 5-ALA addition (1.0% or 10.0% respectively). However, CHT film containing 10.0% of 5-ALA can be a potential delivery system for topical use in the treatment of tumors of the oral cavity using PDT because it favored the retention of 5-ALA in this tissue and has shown convenient mucoadhesion.

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Keywords
Photodynamic therapy; 5-Aminolevulinic acid; Mucoadhesive film; Chitosan; Oral cancer
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 140, November 2014, Pages 266–275
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us