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Solvatochromic behaviour and larvicidal activity of acridine-3-carboxylates

Paper ID Volume ID Publish Year Pages File Format Full-Text
29963 44448 2014 6 PDF Available
Title
Solvatochromic behaviour and larvicidal activity of acridine-3-carboxylates
Abstract

•Synthesis of acridine-3-carboxylate achieved.•Solvatochromic study was evaluated.•Larvicidal activity against A. stephensi and H. maculate were done.

A new series of substituted ethyl 10-chloro-4-(3,4-dimethoxyphenyl)-2-hydroxy-12-phenyl-1,4,5,6-tetrahydrobenzo[a]acridine-3-carboxylates, 3a–e have been synthesized through NaOH base mediated cyclocondensation of (E)-7-chloro-2-(3,4-dimethoxybenzylidene)-9-phenyl-3,4-dihydroacridin-1(2H)-ones, 1a–e with ethyl acetoacetate. Structures of these synthesized molecules were studied by FT-IR, 1H NMR, 13C NMR and EI-MS. And all the synthesized compounds were evaluated for their UV-absorption studies with various metal solutions. Acridine-3-carboxylate derivatives were tested against fourth instar larvae of Anopheles stephensi and Hippobosca maculata. Among those compounds, 3b and 3e have good larvicidal activities against both A.stephensi and H.maculata. Toxicity of compounds, 3b and 3e compounds were evaluated with the reference non-target aquatic species like, Sphaerodema annulatum Fabricius (Heteroptera: Belostomatidae) and Zyxomma petiolatum Rambur (Odonata: Libellulidae) results very low LC50 values revels that, the synthetic compounds are non toxic.

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Keywords
Acridine-3-carboxylate; Cyclocondensation; UV absorption studies; Larvicidal activity
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Solvatochromic behaviour and larvicidal activity of acridine-3-carboxylates
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 140, November 2014, Pages 359–364
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us