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Effects of bio-compatible metal ions on rufloxacin photochemistry, photophysics and photosensitization: Copper(II)

Paper ID Volume ID Publish Year Pages File Format Full-Text
29997 44451 2010 9 PDF Available
Title
Effects of bio-compatible metal ions on rufloxacin photochemistry, photophysics and photosensitization: Copper(II)
Abstract

The presence of copper(II) in the micromolar range modulates the photodegradation rate of the fluoroquinolone Rufloxacin (RFX), both under air and in nitrogen saturated aqueous solution. The photodegradation rate of RFX under aerobic conditions decreases in the presence of metal ions, and no change in the nature of the photoproducts is observed. In anaerobic media, RFX photodegradation rate increases with increasing copper(II) concentration and the photoproducts distribution changes.Copper(II) inhibits formation of type II products of 2′-deoxyguanosine diagnostic of photosensitization mediated by singlet oxygen. The overall results provide a clear example demonstrating how a bio-compatible trace element influences efficiently not only the bioavailability of a drug but also its molecular mechanism of photodegradation and photosensitization.

Keywords
Fluoroquinolone; Phototoxicity; Photochemistry; DNA; Copper
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Effects of bio-compatible metal ions on rufloxacin photochemistry, photophysics and photosensitization: Copper(II)
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 101, Issue 3, 2 December 2010, Pages 295–303
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
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