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Photophysical evaluation of mTHPC-loaded HSA nanoparticles as novel PDT delivery systems

Paper ID Volume ID Publish Year Pages File Format Full-Text
30003 44451 2010 8 PDF Available
Title
Photophysical evaluation of mTHPC-loaded HSA nanoparticles as novel PDT delivery systems
Abstract

Controlled drug release is one of the main goals of recent developments in drug carrier systems. In this work human serum albumin (HSA) nanoparticles as carriers for 5-, 10-, 15-, 20-Tetrakis (3-hydroxyphenyl)-chlorin (mTHPC) were investigated. The photophysical properties of mTHPC–HSA nanoparticles in dependence of loading ratio and level of HSA cross-linking were determined. Further the drug release after uptake by Jurkat cells and in vitro singlet oxygen kinetics were examined.The loading ratio of the mTHPC–HSA nanoparticles turned out to be of major importance for the PDT relevant electronic parameters in solution. Therefore, only HSA nanoparticles with low mTHPC-loading ratio generate singlet oxygen in D2O. However, after cellular uptake all mTHPC–HSA samples generate singlet oxygen in Jurkat cells, but the decomposition rate depends on the level of HSA cross-linking.

Keywords
Photodynamic Therapy (PDT); Nanoparticles; mTHPC; HSA; Singlet oxygen
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Photophysical evaluation of mTHPC-loaded HSA nanoparticles as novel PDT delivery systems
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 101, Issue 3, 2 December 2010, Pages 340–347
Authors
, , , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us