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Drug delivery strategies for photodynamic antimicrobial chemotherapy: From benchtop to clinical practice

Paper ID Volume ID Publish Year Pages File Format Full-Text
30010 44452 2009 10 PDF Available
Title
Drug delivery strategies for photodynamic antimicrobial chemotherapy: From benchtop to clinical practice
Abstract

Light and photosensitizer-mediated killing of many pathogens, termed photodynamic antimicrobial chemotherapy (PACT), has been extensively investigated in vitro. A wide range of organisms from the Gram-positive Staphylococcus aureus to the Gram-negative Pseudomonas aeruginosa have been proven to be susceptible to PACT. Multidrug-resistant strains are just as susceptible to this treatment as their naïve counterparts. Both enveloped and non-enveloped viruses have demonstrated susceptibility in vitro, in addition to fungi and protozoa. Significantly, however, no clinical treatments based on PACT are currently licensed. This paper provides a comprehensive review of work carried out to date on delivery of photosensitizers for use in PACT, including topical, intranasal and oral/buccal delivery, as well as targeted delivery. We have also reviewed photo-antimicrobial surfaces. It is hoped that, through a rational approach to formulation design and subsequent success in small-scale clinical trials, more widespread use will be made of PACT in the clinic, to the benefit of patients worldwide.

Keywords
Photodynamic antimicrobial chemotherapy; Drug delivery; Targeting
First Page Preview
Drug delivery strategies for photodynamic antimicrobial chemotherapy: From benchtop to clinical practice
Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 95, Issue 2, 4 May 2009, Pages 71–80
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering