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Strategies to optimize photosensitizers for photodynamic inactivation of bacteria

Paper ID Volume ID Publish Year Pages File Format Full-Text
30021 44454 2015 9 PDF Available
Title
Strategies to optimize photosensitizers for photodynamic inactivation of bacteria
Abstract

The Infectious Diseases Society of America (IDSA) highlights that over the past several years, the number of new antibacterial drugs approved continues to decrease (Boucher et al., 2009) [1]. Bacteria are very good in developing resistance against antibiotics in a short time. Therefore new approaches like antibacterial photodynamic inactivation of bacteria (aPDI) will become more important in the future as antimicrobial resistance is expected to continue to increase. This review summarises the potential of the susceptibility of bacteria to aPDI and the strategies to optimize leading photosensitizers which are useful for aPDI. The most appropriate photosensitizers belonging to the chemical classes of phenothiazinium, porphyrine, fullerene and perinaphthenone. They all share the following characteristics: positively-charged, water-soluble and photostable. Taken together the most promising clinical applications of aPDI are (i) decolonization of pathogens on skin, (ii) treatments of the oral cavity like periodontitis and root canal infection and (iii) superinfected burn wounds, because these are relatively accessible for photosensitizer application and illumination.

•Decolonization of bacteria by aPDI.•Both killing of bacteria and stimulation of host immune defense by aPDI.•Photosensitizers for diagnostic imaging with efficient antimicrobial activity.•So far no acquired/adaptive aPDI-resistance observed.

Keywords
Phenothiazinium; Porphyrines; Fullerenes; Perinaphthenone; Vitamin B2; Susceptibility; Wounds; Bacteria
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Strategies to optimize photosensitizers for photodynamic inactivation of bacteria
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 150, September 2015, Pages 2–10
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us